Table 3.
Cox regression models for overall and progression-free survival in EOC patients
| Progression-free survival |
Overall survival |
|||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Univariate | ||||
| ctDNA | ||||
| Positive | 1 | < 0.001 | 1 | 0.012 |
| Negative | 0.25 (0.13-0.50) | 0.31 (0.12-0.77) | ||
| Histology | ||||
| Clear cell | 1 | 0.477 | 1 | 0.167 |
| Others | 0.78 (0.40-1.56) | 0.25 (0.21-1.31) | ||
| Stage | ||||
| I/II | 1 | < 0.001 | 1 | < 0.001 |
| III/IV | 8.16 (3.93-16.93) | 15.55 (5.89-48.53) | ||
| Residual tumor | ||||
| No | 1 | < 0.001 | 1 | < 0.001 |
| Yes | 6.64 (3.17-13.66) | 6.96 (2.73-18.34) | ||
| Age (yr) | ||||
| > 57 | 1 | 0.069 | 1 | 0.309 |
| ≤ 57 | 1.89 (0.95-3.84) | 1.60 (0.65-4.17) | ||
| Multivariate | ||||
| ctDNA | ||||
| Positive | 1 | 0.010 | 1 | 0.410 |
| Negative | 0.38 (0.18-0.79) | 0.65 (0.24-1.83) | ||
| Histology | ||||
| Clear cell | 1 | 0.137 | 1 | 0.006 |
| Others | 0.56 (0.27-1.20) | 0.20 (0.059-0.64) | ||
| Stage | ||||
| I/II | 1 | 0.001 | 1 | < 0.001 |
| III/IV | 5.26 (2.11-12.91) | 20.41 (5.34-89.12) | ||
| Residual tumor | ||||
| No | 1 | 0.006 | 1 | 0.107 |
| Yes | 3.41 (1.43-7.90) | 2.57 (0.81-8.16) | ||
| Age (yr) | ||||
| > 57 | 1 | 0.010 | 1 | 0.041 |
| ≤ 57 | 2.61 (1.26-5.67) | 2.97 (1.04-9.10) | ||
EOC, epithelial ovarian cancer; HR, hazard ratio; CI, confidence interval; ctDNA, circulating tumor DNA.