Table 1.
Characteristics of gastric cancer patients with MSS/MSI-L and MSI-H (cohort 1)
| Characteristic | MSS/MSI-L (n=318, 88.6%) | MSI-H (n=41, 11.4%) | p-value |
|---|---|---|---|
| Age (yr) | |||
| Median (range) | 60 (28-87) | ||
| < 70 | 269 (92.4) | 22 (7.6) | < 0.001 |
| ≥ 70 | 49 (72.1) | 19 (27.9) | |
| Sex | |||
| Male | 214 (90.7) | 22 (9.3) | 0.083 |
| Female | 104 (84.6) | 19 (15.4) | |
| Operation | |||
| Total gastrectomy | 109 (93.2) | 8 (6.8) | 0.066 |
| Subtotal gastrectomy | 191 (85.3) | 33 (14.7) | |
| Partial gastrectomy | 17 (100) | 0 | |
| Whipple | 1 (100) | 0 | |
| Histology | |||
| Tubular, well to poorly differentiated | 253 (86.9) | 38 (13.1) | 0.045 |
| Poorly cohesive, signet ring cell type | 42 (100) | 0 | |
| Other histological variants | 23 (88.5) | 3 (11.5) | |
| Laurena) | |||
| Diffuse | 126 (92.0) | 11 (8.0) | 0.028 |
| Intestinal | 147 (84.0) | 28 (16.0) | |
| Mixed | 42 (95.5) | 2 (4.5) | |
| Location | |||
| Upper third | 21 (100) | 0 | 0.005 |
| Mid third | 169 (92.3) | 14 (7.7) | |
| Lower third | 128 (82.6) | 27 (17.4) | |
| Stage | |||
| Ib | 65 (85.5) | 11 (14.5) | 0.285 |
| IIA | 71 (85.5) | 12 (14.5) | |
| IIB | 56 (90.3) | 6 (9.7) | |
| IIIA | 36 (83.7) | 7 (16.3) | |
| IIIB | 58 (95.1) | 3 (4.9) | |
| IIIC | 32 (94.1) | 2 (5.9) | |
| Lymphatic | |||
| Absent | 127 (92.7) | 10 (7.3) | 0.054 |
| Present | 191 (86.0) | 31 (14.0) | |
| Venous | |||
| Absent | 271 (88.0) | 37 (12.0) | 0.386 |
| Present | 47 (92.2) | 4 (7.8) | |
| Perineural | |||
| Absent | 136 (84.5) | 25 (15.5) | 0.027 |
| Present | 182 (91.9) | 16 (8.1) | |
| Adjuvant chemotherapy | |||
| Not applied | 143 (78.1) | 40 (21.9) | 0.113 |
| Applied | 149 (84.7) | 27 (15.3) |
Values are presented as number (%) unless otherwise indicated.
a)
Unknown patients (n=3).