Table 1.
Association analysis of the FGFR4 Gly388Arg polymorphism and clinicopathological parameters in gastric cancer patients
| Variable | Total (n=102) | GG (n=45) | GA+AA (n=57) | Pearson’s χ2 value | p-value |
|---|---|---|---|---|---|
| Age (yr) | |||||
| < 60 | 52 | 23 | 29 | 0.001 | > 0.99 |
| ≥ 60 | 50 | 22 | 28 | ||
| Sex | |||||
| Male | 74 | 35 | 39 | 1.105 | 0.373 |
| Female | 28 | 10 | 18 | ||
| Tumor size (cm) | |||||
| < 4 | 67 | 30 | 37 | 0.004 | > 0.99 |
| ≥ 4 | 34 | 15 | 19 | ||
| Differentiation | |||||
| G1+G2 | 44 | 16 | 28 | 1.887 | 0.227 |
| G3+G4 | 58 | 29 | 29 | ||
| T category | |||||
| T1+T2 | 43 | 24 | 19 | 4.125 | 0.047 |
| T3+T4 | 59 | 21 | 38 | ||
| N category | |||||
| N0 | 47 | 29 | 28 | 0.607 | 0.436 |
| N1+N2+N3 | 54 | 26 | 28 | ||
| M category | |||||
| M0 | 95 | 41 | 51 | 2.713 | 0.130 |
| M1 | 7 | 1 | 6 | ||
| Borrmann type | |||||
| Local type (early GC+Ⅰ+Ⅱ) | 50 | 15 | 35 | 3.494 | 0.071 |
| Infiltrating type (Ⅲ+Ⅳ) | 52 | 25 | 27 | ||
| Lauren type | |||||
| Intestinal type | 45 | 17 | 28 | 0.070 | 0.840 |
| Diffuse infiltration type | 57 | 23 | 34 | ||
| WHO type | |||||
| Tubular adenocarcinoma | 42 | 17 | 25 | 3.264 | 0.515 |
| Papillary adenocarcinoma | 3 | 0 | 3 | ||
| Mucous adenocarcinoma | 3 | 2 | 1 | ||
| Signet ring cell carcinoma | 18 | 8 | 10 | ||
| Poorly differentiated adenocarcinoma | 36 | 13 | 23 | ||
| FGFR4 status | |||||
| Low expression | 33 | 17 | 16 | 1.083 | 0.394 |
| High expression | 69 | 28 | 41 | ||
| STAT3 status | |||||
| Negative | 37 | 14 | 23 | 0.929 | 0.408 |
| Positive | 65 | 31 | 34 | ||
| p-STAT3 status | |||||
| Negative | 46 | 27 | 19 | 7.222 | 0.009 |
| Positive | 56 | 18 | 38 | ||
| Vimentin status | |||||
| Negative | 41 | 24 | 17 | 5.781 | 0.025 |
| Positive | 61 | 21 | 40 | ||
| E-cadherin status | |||||
| Negative | 35 | 12 | 23 | 2.089 | 0.208 |
| Positive | 67 | 33 | 34 |
FGFR4, fibroblast growth factor receptor 4; GC, gastric cancer; WHO, World Health Organization.