Table 2.
Overall objective response
| Total (n=299) | Histology |
Smoking |
|||
|---|---|---|---|---|---|
| Squamous (n=85) | Adenocarcinoma (n=198) | Never (n=108) | Former or current (n=191) | ||
| Objective response ratea) | 53 (18) | 21 (25) | 27 (14) | 13 (12) | 40 (21) |
| Disease control rateb) | 145 (49) | 48 (56) | 85 (43) | 45 (42) | 100 (52) |
| Best overall response | |||||
| CR | 4 (2) | 2 (2) | 2 (1) | 1 (1) | 3 (2) |
| PR | 49 (16) | 19 (22) | 25 (13) | 12 (11) | 37 (19) |
| SD | 92 (31) | 27 (32) | 58 (29) | 32 (30) | 60 (31) |
| PD | 111 (37) | 28 (33) | 79 (40) | 43 (40) | 68 (36) |
| NE | 43 (14) | 1 (1) | 0 | 0 | 1 (1) |
| Duration of responsec) (mo) | 21.03 (0.79+ to 33.15+) | 16.9 (1.94 to 33.08+) | 26.8 (0.79+ to 32.85+) | 20.4 (2.43 to 32.39+) | 26.8 (0.79+to 33.15+) |
Values are presented as number (%) or median (range). CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; NE, not evaluable. a)Best overall response is CR or PR, b)Best overall response is CR or PR or SD, c)The duration of response was defined as the time from the date of first response (CR/PR) to the date of first documented disease progression/death (event), or last tumor assessment (censored).