Skip to main content
. 2020 Jun 5;25(11):2685–2694. doi: 10.1038/s41380-020-0801-x

Fig. 2. CAR and its active metabolites are detectable in the brain of maternally exposed offspring and results in long-lasting sterol changes.

Fig. 2

CAR (a) was quantified by LC-MS/MS in the brain of WT pups exposed to the drug in utero. Vehicle-treated control animals are not denoted in the figure, as they had no detectable CAR or metabolite levels. Levels of CAR-derived metabolites are depicted in Supplementary Fig. 4. b 7-DHC levels are presented as fold increases over control (FIOC: CAR-treated/SAL-treated pups) within each genotype over the course of 30 days after birth (at P0, P7, P14, P21, and P30). Each symbol corresponds to an individual pup brain; filled and opened symbols denote males and females, respectively; bars correspond to the mean ± SEM; statistical significance: ***p < 0.001; ****p < 0.0001. The chemical structures for cariprazine and its metabolites are depicted in Supplementary Fig. 1.