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SPR based equilibrium dissociation constants (KD) and kinetic parameters for the interaction of Aβ1-42 with SA, CH and CO using the BIA evaluation v.4.1 software. Data reported were obtained through SPR analyses using small molecules as analyte on immobilized Aβ1-42.
| kon (M−1s−1 × 104) | koff (s−1 × 10−3) | KD (μM) | |
|---|---|---|---|
| Sanguinarine (SA) | 13.1 | 6.07 | 463 |
| Cheletrine (CH) | 5.14 | 19.7 | 3.83∗10 3 |
| Coralyne (CO) | 983 | 11.4 | 11.6 |
