Table 1.
Baseline Characteristics, Lacunes, Cerebral Microbleeds, and Plasma Lipid Levels (N=548)
| Women (N=267) | Men (N=281) | P | |
|---|---|---|---|
| Characteristics | Mean(range)/N(%) | Mean(range)/N(%) | Value |
| Age (years) | 68.4 (60.4, 92.2) | 67.4 (60.0, 92.3) | 0.537 |
| Education (years) | 14.5 (0, 20) | 15.3 (6, 20) | <0.001 |
| APOE (≥1 allele) | 91 (34.1%) | 77 (27.4%) | 0.090 |
| Hypertension | 138 (51.7%) | 167 (59.4%) | 0.068 |
| Diabetes | 33 (12.4%) | 47 (16.7%) | 0.148 |
| Lacune type | |||
| Any | 20 (7.5%) | 48 (17.1%) | <0.001 |
| Cortical | 6 (2.3%) | 15 (5.3%) | 0.062 |
| Subcortical | 13 (4.9%) | 38 (13.5%) | <0.001 |
| CMBs type* | |||
| Total | 0.43 (0, 74) | 0.51 (0, 22) | 0.004 |
| Any | 28 (10.5%) | 53 (18.9%) | 0.006 |
| Lobar | 19 (7.1%) | 45 (16.0%) | 0.001 |
| Deep | 10 (3.7%) | 8 (2.8%) | 0.555 |
| Ceramides, ng/ml | |||
| C14:0 | 12.0 (3.0, 65.7) | 9.0 (6.7, 12.4) | <0.001 |
| C16:0 | 97.3 (47.7, 204.3) | 86.1 (24.7, 175.7) | <0.001 |
| C18:0 | 89.5 (23.8, 246.2) | 74.0 (13.3, 212.2) | <0.001 |
| C18:1 | 3.0 (0.06, 14.05) | 2.7 (0.4, 15.8) | 0.057 |
| C20:0 | 254.3 (111.4, 728.6) | 222.3 (87.6, 486.4) | <0.001 |
| C22:0 | 766.7 (341.9, 1487.6) | 705.3 (298.8, 1488.0) | <0.001 |
| C23:0 | 456.3 (72.3, 919.3) | 407.6 (37.6, 953.0) | <0.001 |
| C24:0 | 1261.0 (448.7, 2431.1) | 1222.8 (102.0, 2270.9) | 0.194 |
| C24:1 | 336.1 (151.9, 711.6) | 306.5 (108.4, 625.3) | <0.001 |
| Ceramide ratios | |||
| C16:0_24:0 | 0.08 (0.04, 0.20) | 0.08 (0.03, 0.89) | 0.222 |
| C18:0_24:0 | 0.07 (0.02, 0.26) | 0.06 (0.01, 0.56) | 0.002 |
| C24:1_24:0 | 0.28 (0.13, 0.75) | 0.27 (0.09, 2.55) | 0.314 |
| Ceramide score | 5.3 (0, 12) | 3.8 (0, 12) | <0.001 |
CMBs indicates cerebral microbleeds. P-values are from Student’s t-test for all continuous variables, except total CMBs which required a Wilcoxon rank sum test due to the skewed distribution, and are from chi-square tests for categorical variables.
*
The median number of total, lobar, and deep CMBs was 0 for both women and men.