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. 2020 Oct 21;10:17885. doi: 10.1038/s41598-020-74628-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced rhodopsin concentration and aberrant ultrastructure of photoreceptor OS during disease progression in Prcd-KO mice. (A) Quantification of total rhodopsin (pmol rhodopsin/retina) in WT and Prcd-KO retina at P30. (B) Quantification of total rhodopsin (pmol rhodopsin/retina) in WT and Prcd-KO retina at P120. Data is reported as the mean (unpaired, two-tailed t-test; ***p = .000072). (C) TEM image of the photoreceptor OS and well organized disc membranes at P120 (WT). (D-F) TEM ultrastructure of photoreceptor OS at various ages in Prcd-KO retina show the progressive disruption of OS structure from (D) P30, (E) P60, and (F) P120. Arrowheads indicate the defective and disorganized disc membranes. Scale bar = 500 nm.