Table 1.
The clinicopathological characteristics and treatment of the included 3152 colorectal signet ring cell carcinoma patients.
| Characteristic | Total | Unmarried | Married | P-value |
|---|---|---|---|---|
| Year at diagnosis | 0.068 | |||
| 2004–2007 | 1066 (33.82%) | 440 (32.00%) | 626 (35.23%) | |
| 2008–2011 | 1022 (32.42%) | 443 (32.22%) | 579 (32.58%) | |
| 2012–2015 | 1064 (33.76%) | 492 (35.78%) | 572 (32.19%) | |
| Insured status | 0.405 | |||
| Uninsured/unknown | 969 (30.74%) | 412 (29.96%) | 557 (31.34%) | |
| Any medicaid/insured | 2183 (69.26%) | 963 (70.04%) | 1220 (68.66%) | |
| Age | < 0.001 | |||
| < 65 | 1677 (53.20%) | 665 (48.36%) | 1012 (56.95%) | |
| ≥ 65 | 1475 (46.80%) | 710 (51.64%) | 765 (43.05%) | |
| Gender | < 0.001 | |||
| Female | 1534 (48.67%) | 805 (58.55%) | 729 (41.02%) | |
| Male | 1618 (51.33%) | 570 (41.45%) | 1048 (58.98%) | |
| Race | < 0.001 | |||
| Black | 299 (9.49%) | 173 (12.58%) | 126 (7.09%) | |
| White | 2584 (81.98%) | 1115 (81.09%) | 1469 (82.67%) | |
| Other | 269 (8.53%) | 87 (6.33%) | 182 (10.24%) | |
| Primary site | 0.213 | |||
| Cecum–transverse colon | 1901 (60.31%) | 841 (61.16%) | 1060 (59.65%) | |
| Descending colon–sigmoid | 493 (15.64%) | 206 (14.98%) | 287 (16.15%) | |
| Multiple | 48 (1.52%) | 28 (2.04%) | 20 (1.13%) | |
| Rectum | 623 (19.77%) | 262 (19.05%) | 361 (20.32%) | |
| Unknown | 87 (2.76%) | 38 (2.76%) | 49 (2.76%) | |
| Grade | 0.233 | |||
| Grade I/II | 171 (5.43%) | 64 (4.65%) | 107 (6.02%) | |
| Grade III/IV | 2419 (76.74%) | 1067 (77.60%) | 1352 (76.08%) | |
| Unknown | 562 (17.83%) | 244 (17.75%) | 318 (17.90%) | |
| Tumor size | 0.002 | |||
| ≤ 5 cm | 1173 (37.21%) | 494 (35.93%) | 679 (38.21%) | |
| > 5 cm | 1221 (38.74%) | 578 (42.04%) | 643 (36.18%) | |
| Unknown | 758 (24.05%) | 303 (22.04%) | 455 (25.60%) | |
| AJCC stage | 0.968 | |||
| I | 147 (4.66%) | 64 (4.65%) | 83 (4.67%) | |
| II | 444 (14.09%) | 192 (13.96%) | 252 (14.18%) | |
| III | 1156 (36.68%) | 511 (37.16%) | 645 (36.30%) | |
| IV | 1405 (44.57%) | 608 (44.22%) | 797 (44.85%) | |
| Surgery | 0.053 | |||
| No surgery | 650 (20.62%) | 287 (20.87%) | 363 (20.43%) | |
| Local tumor excision /Partial colectomy | 828 (26.27%) | 332 (24.15%) | 496 (27.91%) | |
| Total colectomy | 1674 (53.11%) | 756 (54.98%) | 918 (51.66%) | |
| Lymph node dissection | 0.991 | |||
| None or biopsy | 847 (26.87%) | 368 (26.76%) | 479 (26.96%) | |
| 1–3 | 83 (2.63%) | 36 (2.62%) | 47 (2.64%) | |
| ≥ 4 | 2222 (70.49%) | 971 (70.62%) | 1251 (70.40%) | |
| Chemotherapy | < 0.001 | |||
| No/unknown | 1312 (41.62%) | 664 (48.29%) | 648 (36.47%) | |
| Yes | 1840 (58.38%) | 711 (51.71%) | 1129 (63.53%) | |
| Radiotherapy | 0.077 | |||
| No/unknown | 2726 (86.48%) | 1206 (87.71%) | 1520 (85.54%) | |
| Yes | 426 (13.52%) | 169 (12.29%) | 257 (14.46%) |