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. 2020 Oct 21;10:17899. doi: 10.1038/s41598-020-74882-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prima-1^Met pharmaco-genomic and transcriptomic associations. (A) Dose–response curve from primary screen. (B) Violin plot of AUC values vs TP53 status for Prima-1^Met (p > 0.999) and AZD7762 (p < 0.01). (C) List of ssGSEA pathways that had a significant (p < 0.05) and strong correlation (absolute value of Pearson r coefficient ≥ 0.70) with the AUC of Prima-1^Met. (D) Example of the correlation between Prima-1^Met to KEGG glutathione metabolism pathway activity.