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. 2020 Oct 21;10:17921. doi: 10.1038/s41598-020-74496-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Determining NMDAR-dependent LTD in the LHb regions. (a, b) Top, The proposed ƒEPSP sweep shows the change in baseline (black trace, from black arrow in bottom) and after 55 min of LFS transmission (red trace, from red arrow in bottom). Bottom, The LFS (900 pulses at 1 Hz) elicited robust LTD. The regulation of LFS-induced LTD by selective glutamate receptor antagonists (a) and NMDAR subtype antagonists (b). (c) Summary histogram showing modulation of LTD by selective glutamate receptor antagonists (one-way ANOVA, F[4, 42] = 39.14; Dunnett’s post-hoc test as condition vs. baseline; LFS-LTD, 71.9 ± 4.2%, n = 10, ****P < 0.0001; D-AP5, 96.7 ± 1.7%, n = 8, ns, P = 0.5884; NASPM, 100.4 ± 2.1%, n = 7, ns, P > 0.9999; LY367385, 103.7 ± 4.2%, n = 6, ns, P = 0.7828). (d) Bar graph shows LTD is regulated by selective NMDAR subtype antagonist (one-way ANOVA, F[4, 42] = 37.97; Dunnett’s post-hoc test as condition vs. baseline; NVP-AAM 077, 99.1 ± 2.7%, n = 7, ns, P = 0.9533; ifenprodil, 97.4 ± 3.0%, n = 7, ns, P = 0.2148).