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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2020 Jul 17;66:104–111. doi: 10.1016/j.ceb.2020.05.012

Figure 1. Mechanotransduction in the developing brain.

Figure 1.

(A) The developing brain experiences a variety of mechanical cues. Left panels show a schematic of a coronal cross section of half of the developing brain, and the fluid-based forces, hydrostatic pressure (upper left) and shear flow (lower left) impinging against cells that line the ventricles. Tissue stiffness (upper right) is modulated by extracellular matrix components or by cellular density. The actomyosin cytoskeleton (lower right) connects to the extracellular matrix through focal adhesions and is integral to cellular mechanotransduction during development. CSF = cerebrospinal fluid, ECM = extracellular matrix. (B) The molecules and cellular structures involved in the mechanotransduction in the developing neuroepithelium. ap = apical border.