Table 1.

Antimalarial and cytotoxicity profiles of (±)-moxiquindole (MQN).

	aEC50 (µM)				bCC50 (µM)
Compound	PfNF54		Pf3D7	PfDd2	Vero	SW872	cRI	dSI
CQ	0.009		0.020 ± 0.001	0.230 ± 0.028	nd	nd	11.500	nd
ART	nd		0.015 ± 0.001	0.025 ± 0.070	nd	nd	1.667	nd
AS	0.004		Nd	nd	nd	nd	nd	nd
MQN	0.686 ± 0.061		1.865 ± 0.001	1.730 ± 0.070	> 100	> 100	0.928	> 50

^a,bMeans ± SD of two independent experiments each done in duplicate.

^cEC₅₀PfDd2/EC₅₀Pf3D7.

^dCC₅₀Vero/EC₅₀Pf3D7.

CQ: Chloroquine, ART: Artemisinin, AS: Artesunate, MQN: (±)-moxiquindole nd: not determined RI: Resistance index, SI: Selectivity index.