Table 2.

Stage-specific activities of (±)-moxiquindole determined by a Giemsa-based cytological profiling method.

6 hpi	R	T	30 hpi	R	T	S	42 hpi	R	S
ART	5.85	0.11	ART	0.18	7.64	0.19	ART	0.23	5.71
CQ	5.61	0.15	CQ	0.22	7.09	0.33	CQ	0.87	1.79
E64	1.12	0.95	E64	0.15	1.27	3.62	E64	0.09	6.57
MQN	5.48	0.14	MQN	0.12	7.73	0.33	MQN	0.15	6.21

Tightly synchronized P. falciparum parasites (3D7 strain) were treated with 10 μM final concentration of each compound at either the 6 hpi (hour post invasion, early ring), 30 hpi (mid trophozoites), or 42 hpi (midschizont) for 24 h. Giemsa-stained thin smears were prepared, parasitemia determined and stage accumulation indices for each treatment time-point was calculated. R: rings; T: trophozoites; S: schizonts.