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. Author manuscript; available in PMC: 2021 Feb 24.
Published in final edited form as: Nat Immunol. 2020 Aug 24;21(11):1327–1335. doi: 10.1038/s41590-020-0778-2

Extended Data Fig. 1. SARS CoV-2 infection and hACE2 expression in the K18-hACE2 model.

Extended Data Fig. 1

a. Six-week-old male and female K18-hACE2 transgenic mice were inoculated via the intranasal route with the indicated PFU doses of SARS-CoV-2, and weight change was monitored (one experiment, n = 4, symbols represent the mean ± SEM). b. mRNA expression levels of hACE2 in the lung, kidney, heart, brain, spleen, duodenum, colon, and ileum of naive K18 hACE2 mice (two experiments, n = 5). c. mRNA expression levels of hACE2 in the lungs of K18 hACE2 mice at 2, 4, and 7 dpi following SARS-CoV-2 infection (two experiments, n = 4 per time point, bars represent the mean ± SEM ).