Fig. 4.

NEDA outcomes of the CAMMS223 long-term follow-up cohort over 12 years. Percentage of patients with NEDA from Year 7 to Year 12 (CAMMS03409 extension study enrollment until end of Year 12) in the long-term follow-up cohort. ^aKaplan–Meier estimates. ^bNumber at risk is the number of patients who remained on study and did not yet have disease activity. NEDA is defined as absence of both clinical disease activity (absence of both relapses and 6-month CDW) and MRI disease activity (absence of new gadolinium-enhancing T1 and new/enlarging T2 hyperintense lesions). CDW confirmed disability worsening, CI confidence interval, NEDA no evidence of disease activity