Table 2.
Plasma concentrations as a function of the CYP2C9 alleles. The median values are given with the interquartile distances and the significance values
| CYP2C9 | |||||
|---|---|---|---|---|---|
| Wild-type | Allele*2 | Allele*3 | |||
| n | 43 | 13 | pa | 14 | pa |
| Δ9-THC ng/ml | 4.4 (2.1–7.3) | 5.4 (3.8–8.3) | n. s. | 3.0 (1.7–5.7) | n. s. |
| 11-OH-Δ9-THC ng/ml | 2.0 (0.9–2.8) | 1.8 (0.8–2.4) | n. s. | 1.8 (1.0–2.7) | n. s. |
| Δ9-THC-COOH ng/ml | 39.3 (24.0–58.7) | 22.9 (20.0–40.1) | 0.068 | 18.9 (11.6–28.8) | 0.001 |
| [Δ9-THC ng/ml/Δ9-THC-COOH ng/ml] | 0.12 (0.07–0.17) | 0.20 (0.17–0.33) | 0.011 | 0.20 (0.10–0.40) | 0.032 |
ap values were determined by the Mann-Whitney U test and are derived by comparing the respective variation with the wild type; if the p value is below 0.05, the difference was considered statistically significant (p values between 0.05 and 0.1 are included to show possible trends)
n. s. not significant