Table 4.
Plasma concentrations as a function of the CYP2C19 alleles. The median values are given with the interquartile distances and the significance values
| CYP2C19 | |||||
|---|---|---|---|---|---|
| Wild-type | Allele*2 | Allele*17 | |||
| n = 16 | n = 13 | pa | n = 17 | pa | |
| Δ9-THC ng/ml | 4.4 (2.0–7.9) | 3.4 (1.7–5.4) | n. s. | 5.9 (3.0–7.9) | n. s. |
| 11-OH-Δ9-THC ng/ml | 2.1 (1.0–3.0) | 1.8 (0.7–2.7) | n. s. | 2.1 (1.0–3.0) | n. s. |
| Δ9-THC-COOH ng/ml | 43.9 (24.0–60.8) | 40.7 (27.5–59.0) | n. s. | 36.8 (29.7–56.3) | n. s. |
| [Δ9-THC ng/ml/Δ9-THC-COOH ng/ml] | 0.13 (0.06–0.17) | 0.09 (0.04–0.14) | n. s. | 0.14 (0.09–0.18) | n. s. |
ap values were determined using the Mann-Whitney U test and are derived from the comparison of the respective variation with the wild type; if the p value is less than 0.05, the difference was considered statistically significant
n. s. not significant