Extended Data Fig. 4. Allergic airway inflammatory responses in mice with T_reg cell-specific Notch1 or Notch2 deletion or global Notch3 deletion.

a-c, AHR in Foxp3^YFPCre, Foxp3^YFPCreNotch1^Δ/Δ, Foxp3^YFPCreNotch2^Δ/Δ, or Foxp3^YFPCreNotch3^–/– mice segregated into PBS, OVA or OVA+UFP-treated groups (200X magnification). d, serum OVA-specific IgE concentrations. e,f, absolute numbers of lung CD4⁺ T cells and eosinophils. g,h, IL-4, IL-13, and IL-17 expression in lung Foxp3^–CD4⁺T_eff (g) and Foxp3⁺CD4⁺T_reg cells (h). Each symbol represents an independent sample. Error bars indicate SEM. Statistical tests: two-way ANOVA with Sidak’s post hoc analysis a-h. Data representative of two or three independent experiments. n=5 mice per group.