Extended Data Fig. 5. T_reg cell-specific Il6r and stat3 deletions attenuate allergic airway inflammation.

a, Representative PAS-stained sections of lung tissues isolated from Foxp3^YFPCre, Foxp3^YFPCreIl6r^Δ/Δ or Foxp3^YFPCreStat3^Δ/Δ mice segregated into PBS, OVA or OVA+UFP-treated groups (200X magnification). b, Inflammation scores in the respective lung tissues. c, AHR in the respective mouse groups in response to methacholine. d,e, serum total and OVA-specific IgE concentrations. f,g, absolute numbers of lung CD4⁺ T cells and eosinophils. h,i, IL-13 and IL-17 expression in lung Foxp3⁺CD4⁺ T_reg (h) and Foxp3^–CD4⁺ T_eff cells (i). Each symbol represents an independent sample. Error bars indicate SEM. Statistical tests: two-way ANOVA with Sidak’s post hoc analysis (b-i). *P<0.05, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Data representative of two or three independent experiments. n=5 mice per group.