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. 2020 Oct 8;33(14):1003–1009. doi: 10.1089/ars.2019.7884

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© Soraia K.P.F. Costa et al. 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — Enhanced analgesic effects of ATB-352 versus ketoprofen on mechanical postoperative allodynia in mice. The presence of mechanical allodynia is indicated by a decrease in the threshold force necessary for the animal response (i.e., paw withdrawal). Mice were orally pretreated with ketoprofen (3, 10, or 30 mg/kg); (A–C), respectively; n = 6, equimolar doses of ATB-352 (4.6, 15, or 46 mg/kg; n = 6), or vehicle (1 mL/kg; n = 6). The control group (sham) did not receive any treatment (n = 6). Data are expressed as mean ± SEM changes in paw withdrawal force thresholds measured before (pre) and 24 h after the incision (post) and then at 0.5, 1, 2, 3, 4, and 5 h after treatment. Red asterisks indicate a significant difference between the mice treated with ATB-352 and the corresponding ketoprofen-treated group (p < 0.05). Data were analyzed by one-way ANOVA, followed by the Bonferroni multiple comparison test.