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. 2020 Oct 8;33(14):1003–1009. doi: 10.1089/ars.2019.7884

FIG. 2.

FIG. 2.

Reduction of pain in the mechanical allodynia model in mice (area under the curve of a 5-h observation period) by ketoprofen versus ATB-352 and effects of pretreatment with a cannabinoid antagonist (AM251; 3 mg/kg i.p.). At a dose of 10 mg/kg, ketoprofen was not effective in reducing pain, in contrast to significant allodynia with an equimolar dose of ATB-352 (15 mg/kg; *p < 0.05 vs. the vehicle-treated group). At a higher dose (30 mg/kg), ketoprofen did produce a significant reduction of mechanical allodynia, comparable with that observed with an equimolar dose of ATB-352 (46 mg/kg). Pretreatment of ketoprofen-treated mice with AM251, a cannabinoid (CB1) antagonist, did not affect the extent of mechanical allodynia. In contrast, the mechanical allodynia observed in mice treated with equimolar doses of ATB-352 was significantly reduced by pretreatment with the CB1 antagonist (βp < 0.05). Data were analyzed by one-way ANOVA, followed by the Bonferroni multiple comparison test, and data are presented as the mean ± SEM (n = 6 per group).