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Levels of anandamide in blood were significantly reduced (p < 0.001) in mice treated with ketoprofen (10 mg/kg) 5 h before sampling, in sharp contrast to the lack of effect of an equimolar dose of ATB-352. Data were analyzed by one-way ANOVA, followed by the Bonferroni multiple comparison test, and data are presented as the mean ± SEM (n = 6 per group).
