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MiR-214 directly regulated the expression levels of PTEN and WWOX to modulate AKT signaling pathway. (A) The binding sites between miR-214 and PTEN 3′-UTR or WWOX 3′-UTR. (B) Relative luciferase activity of PTEN 3′-UTR and WWOX 3′-UTR after miR-214 inhibitor treatment. (C) Expression levels of WWOX, PTEN, AKT signaling-associated proteins after miR-214 inhibitor treatment. ***p < 0.001 and **p < 0.01.
