. 2020 Oct 8;26(10):884–901. doi: 10.1089/acm.2020.0181

Table 2.

Randomized Controlled Trial Modified SIGN Checklist

	Item	Yes/no^a
1	The study addressed an appropriate and clearly focused question.
2	Group assignment was randomized.
3	The sample size was justified by a power calculation.
4	Investigators were blinded to patients' group assignment.
5	Patients were blinded to group assignment.
6	Groups were similar at the start of the trial.
7	The only difference between groups was the treatment of interest.
8	Outcomes were measured in a standard, valid, and reliable way.
9	A power calculation was used and required sample size attained.
10	An intention to treat analysis was performed.
	Total score^b

^{^a}

Rating: “Yes” = 1; “No” or unable to tell from the article = 0.

^{^b}

Scoring—sum of items as follows: 9–10 = high quality, low risk of bias; 6–8 = acceptable quality, moderate risk of bias; <6 = low quality, high risk of bias.