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. 2020 Oct 8;26(10):884–901. doi: 10.1089/acm.2020.0181

Table 5.

Rating the Quality of Evidence Using the Grading of Recommendations Assessment, Development and Evaluation System

Level of evidence Quality rating Explanation of quality rating
A High High level of confidence in the effects of the intervention.
• Several high-quality studies with consistent outcomes
B Moderate Confidence in the effects of the intervention may change with future research findings
• Only one high-quality study or
• Several lower quality studies
C Low Confidence in the effects of the intervention is very likely to change with future research findings
• All studies have severe limitations
D Very Low Uncertainty about the effects of the intervention
• Only expert opinion and/or
• No research evidence or
• Very low-quality evidence

Source: GRADE.103