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Dose-finding study of Alfaxalone and Dexmedetomidine in C57BL/6JOlaHsd mice (n = 10 vehicle; n = 10 BLM).
| Alfa+Dex (mg/kg) | Induction* (min) | Duration* (min) |
|---|---|---|
| 60+0.5 | 1.5 ± 0.7 | 112.5 ± 10.6 |
| 50+0.5 | 2.3 ± 0.4 | 75.0 ± 7.1 |
| 40+0.5 | 2.6 ± 0.9 | 58.4 ± 5.9 |
| 30+0.3 | 3.0 ± 1.3 | 36.3 ± 6.0 |
| 20+0.3 | n.a. | n.a. |
Data are expressed as mean ± SD; n.a., not available.
