Table 1.
A– IECdnRAR are refractory to the early protective effects of RA.
| Genotype | WT | LysMdnRAR | IECdnRAR | |||
|---|---|---|---|---|---|---|
| A– | A– +RAa | A– | A– +RA | A– | A– +RA | |
| Mortalityb (n) | 59% (17) | 9% (11) | 50% (16) | 0% (15) | 71% (21) | 43% (7) |
| Chronicc (n) | 100% (10) | 0% (11) | 88% (8) | 42% (12) | 100% (6) | 0% (4) |
a
RA dosing was started on the day of infection.
b
Fisher exact test was used to determine the effect of RA treatment on mortality and chronic shedding. There was a significant effect of RA treatments on mortality of A– WT and A– LysMdnRAR mice but not A– IECdnRAR mice. There was a significant effect of RA on chronic infection rates in A– WT and A– IECdnRAR mice but not A– LysMdnRAR mice.
c
Mice were continuing to shed >3 logs of bacteria in the feces on day 37 post-infection.