FIGURE 2.

Simulated plasma concentration‐time profile of baloxavir acid (BXA) after oral administration of baloxavir marboxil twice a day on the first day. Each symbol indicates observed data for a single administration. The plasma BXA concentrations were estimated by computing the superposition from observed single‐dosing data in Phoenix WinNonlin Software^®. The simulated values of plasma concentration are described in Table S3. The 90% effective concentration (EC₉₀) value of BXA against A/Kadoma/3/2006 of 0.88 nmol/L (0.42 ng/mL) was based on a previous in vitro study. ⁹ The target plasma concentration of BXA (6.85 ng/mL) was determined in a previous mouse study ³⁶