TABLE 3.

Stability of baloxavir marboxil (BXM), oseltamivir, and cefcapene pivoxil in liver microsomes of a human, ferret, rat, dog, and monkey

Substance	Incubation time (min)	% Residual in liver microsome
		Human	Ferret	Rat	Dog	Monkey	Control (Microsome free)
BXM	10	8.2	98.5	25.3	0.1	0.0	81.3
	20	0.3	98.1	4.6	0.1	0.0	81.7
	30	0.0	90.8	0.6	0.0	0.0	92.1
Oseltamivir	10	89.8	106.5	110.8	115.8	73.6	106.4
	20	64.8	107.2	119.2	109.6	59.1	105.4
	30	49.7	109.0	117.3	110.5	45.2	111.3
Cefcapene pivoxil	10	2.1	3.2	21.6	5.4	0.0	79.3
	20	0.0	0.1	1.6	0.2	0.0	67.7
	30	0.0	0.0	0.1	0.0	0.0	65.4

Data are expressed as the mean of duplicates. Individual values are described in Table S5.