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. 2020 Jun 16;6(4):231–237. doi: 10.1002/cjp2.172

Figure 1.

Figure 1

High‐resolution genomic copy number analyses reveal a subgroup of osteoblastoma harbouring recurrent deletions in 6q and 22q12. (A) SNP array analysis detects recurrent deletions in chromosome arm 6q in five osteoblastomas. (B) Four of them harbour concomitant deletions in chromosome arm 22q. (C) Whole genome paired‐end sequencing (Case 1), whole exome sequencing (Case 2), and SNP array analysis (Cases 5 and 19) show that these deletions cluster to the ZNRF3 and NF2 genes in 22q12. The latter gene is affected by intragenic homozygous deletions in all four cases. Case 15 did not harbour any deletions affecting chromosome 22. Yellow lines mark the positions of the ZNRF3 and NF2 genes.