Figure 4.

Relationships between IL‐6 concentration, disease severity, and quantity of respiratory syncytial virus (RSV). Concentrations of IL‐6 were measured in respiratory secretions of volunteers and were compared with disease measures and viral quantities. A, The cumulative sum of the IL‐6 concentrations vs disease severity as measured by individual volunteer cumulative symptom scores. B, The cumulative sum of IL‐6 concentrations vs disease severity as measured by individual volunteer cumulative nasal mucus weight. C, Comparison of the cumulative sum of IL‐6 concentrations vs area under the curve (AUC) viral load (quantitative real‐time reverse transcriptase‐polymerase chain reaction, qPCR). P values represent the probability that the slopes of the regression lines do not include a slope of zero. The dashed curved lines indicate the 95% confidence interval of the slopes of the regression line (solid line). Similar statistically significant direct relationships were observed when viral AUC was measured by quantitative culture ⁴⁰