Table 1.

WHO criteria for the conduct of COVID‐19 HVCM studies ⁹

Criteria
1	There should be a strong scientific justification
2	The expected benefits should outweigh the risks
3	There should be engagement with the public, appropriate experts and policymakers
4	The research programs should be closely co‐ordinated between researchers, funders, policymakers and regulators
5	The study sites should allow the research to be conducted to the highest scientific, clinical and ethical standards
6	Participants selection criteria should limit and minimise risk
7	COVID‐19 challenge studies should be reviewed by specialised independent research ethics committees
8	There must be a rigorous informed consent procedure