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. 2020 Oct 8;11:581445. doi: 10.3389/fimmu.2020.581445

Figure 2.

Figure 2

Higher expression of IL-33 and ST2 in duodenal epithelium and lamina propria region of active CD patients. (A) Representative images of IL-33 immunofluorescent staining in duodenal mucosae of NC and ACD patients. IL-33 (green), Nuclei (blue). The white arrows show some of the regions with expression of IL-33 associated to cell infiltration. Dashed arrows show cells with IL-33 nuclear localization with a morphology compatible with vascular cells. (B) Relative Fluorescent Density (RFD) of IL-33 in the epithelial compartment and lamina propria. NC (n = 7), ACD patients (n = 10). (C) Representative images of ST2 immunofluorescent staining in duodenal mucosae of NC and ACD patients. ST2 (green), nuclei (blue). (D) RFD of ST2 in the epithelial compartment and lamina propria. NC (n = 4) and ACD patients (n = 6). Unpaired t-test (*p < 0.05; **p < 0.01). The images in A were taken with Leica SP5 microscope with 20X objective and the images in C were taken with Zeiss Apotome with 20X objective.