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. 2020 Oct 8;11:581445. doi: 10.3389/fimmu.2020.581445

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Copyright © 2020 Perez, Ruera, Miculan, Carasi, Dubois-Camacho, Garbi, Guzman, Hermoso and Chirdo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the IL33/ST2 axis and inflammatory markers in duodenal mucosae. (A) Violin plots of qPCR results for IL33 gene (NC = 11, ACD = 15) and IL1RL1 splice variants corresponding to sST2 (NC = 10, ACD = 12) and ST2L (NC = 5, ACD = 7) proteins. (B) Correlation heatmap of Pearson r values between different genes evaluated in ACD and NC individuals. (C) Correlation plot of sST2 mRNA with IL33 mRNA. (D) Correlation plot of ratio IFNB1/IL10 with IL33 mRNA. (E) Correlation plot of IRF1 mRNA with IL33 mRNA. (F) Correlation plot of IRF1 mRNA with sST2 mRNA. All ACD samples are shown as red dots and NC as blue dots, p-value is shown for each correlation. Unpaired T-test was used as the statistical analysis in (A) and Pearson correlation analysis for multiple correlations of different genes in (B–E). The p-value < 0.05 was considered statistically significant.