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. 2020 Oct 8;11:580380. doi: 10.3389/fendo.2020.580380

Table 2.

Association of maternal SCH and adverse pregnancy outcomes according to 2011 ATA standard.

Outcomes ET, n (%) SCH2011, n (%) Unadjusted OR (95% CI) Model I OR (95% CI) Model II OR (95% CI)
ET SCH2011 P-value ET SCH2011 P-value ET SCH2011 P-value
PIH 15 (1.5%) 22 (3.8%) 1 (ref) 2.49 (1.28–4.84) 0.007 1 (ref) 3.86 (1.81–8.23) <0.001 1 (ref) 4.27 (1.95–9.33) <0.001
Preeclampsia 5 (0.5%) 12 (2.1%) 1 (ref) 4.05 (1.42–11.54) 0.009 1 (ref) 6.08 (1.82–20.28) 0.003 1 (ref) 7.40 (2.08–26.35) 0.002
GDM 194 (20%) 116 (19.8%) 1 (ref) 0.99 (0.77–1.28) 0.943 1 (ref) 1.09 (0.83–1.44) 0.524 1 (ref) 1.07 (0.81–1.41) 0.644
CS 353 (36.4%) 216 (36.9%) 1 (ref) 1.03 (0.83–1.27) 0.821 1 (ref) 1.21 (0.96–1.53) 0.115 1 (ref) 1.25 (0.98–1.59) 0.069
Preterm delivery 468 (48.2%) 277 (47.4%) 1 (ref) 0.97 (0.79–1.19) 0.746 1 (ref) 1.14 (0.91–1.43) 0.259 1 (ref) 1.15 (0.92–1.45) 0.223
Postpartum hemorrhage 12 (1.2%) 13 (2.2%) 1 (ref) 1.82 (0.82–4.01) 0.139 1 (ref) 1.48 (0.65–3.33) 0.348 1 (ref) 1.54 (0.68–3.52) 0.303
Placenta previa 13 (1.3%) 11 (1.9%) 1 (ref) 1.41 (0.63–3.17) 0.403 1 (ref) 2.31 (0.96–5.56) 0.062 1 (ref) 2.21 (0.92–5.32) 0.078
Placenta abruption 1 (0.1%) 1 (0.2%) 1 (ref) 1.66 (0.10–26.61) 0.720 1 (ref) 1.99 (0.11–36.51) 0.644 1 (ref) 1.94 (0.09–40.65) 0.670
Dystocia 14 (1.4%) 8 (1.4%) 1 (ref) 0.95 (0.40–2.27) 0.904 1 (ref) 0.94 (0.38–2.33) 0.891 1 (ref) 0.93 (0.38–2.29) 0.868
Low birth weight 26 (2.7%) 25 (4.3%) 1 (ref) 1.62 (0.93–2.84) 0.090 1 (ref) 2.00 (1.06–3.76) 0.032 1 (ref) 1.93 (1.02–3.62) 0.042
Preterm birth 468 (48.2%) 277 (47.4%) 1 (ref) 0.97 (0.79–1.19) 0.746 1 (ref) 1.14 (0.91–1.43) 0.223 1 (ref) 1.15 (0.92–1.45) 0.223
Macrosomia 47 (4.8%) 27 (4.6%) 1 (ref) 0.95 (0.59–1.55) 0.840 1 (ref) 0.94 (0.57–1.57) 0.823 1 (ref) 0.94 (0.56–1.58) 0.801
Fetal distress 17 (1.8%) 15 (2.6%) 1 (ref) 1.48 (0.73–2.98) 0.278 1 (ref) 1.68 (0.79–3.57) 0.179 1 (ref) 1.71 (0.80–3.69) 0.168
Fetal asphyxia 3 (0.3%) 2 (0.3%) 1 (ref) 1.11 (0.18–6.64) 0.912 1 (ref) 0.92 (0.08–10.11) 0.948 1 (ref) 0.86 (0.08–9.36) 0.903
Fetal deformities 12 (1.2%) 2 (0.3%) 1 (ref) 0.27 (0.06–1.23) 0.091 1 (ref) 0.74 (0.12–4.37) 0.736 1 (ref) 0.64 (0.08–4.78) 0.659
Stillbirth 9 (0.9%) 3 (0.5%) 1 (ref) 0.55 (0.15–2.04) 0.373 1 (ref) 0.48 (0.09–2.51) 0.387 1 (ref) 0.53 (0.10–2.96) 0.470
Total adverse 481 (49.5%) 290 (49.6%) 1 (ref) 1.00 (0.82–1.23) 0.989 1 (ref) 1.14 (0.91–1.43) 0.268 1 (ref) 1.17 (0.93–1.47) 0.177
maternal outcomes
Total adverse 513 (52.8%) 299 (51.1%) 1 (ref) 0.93 (0.76–1.15) 0.510 1 (ref) 1.18 (0.94–1.48) 0.150 1 (ref) 1.18 (0.94–1.49) 0.155
neonatal outcomes

Model I, adjusted for maternal age, pregestational BMI, and gestation age; Model II, adjusted for maternal age, pregestational BMI, gestational age, number of previous pregnancies, number of previous births, primiparity, and gestational weight gain.