Table 4.
Summarization of the anticancer studies with different Terminalia species.
| Terminalia sp. | Mechanism/Mode of action | Phytochemicals (compound no.) | Reference |
|---|---|---|---|
| T. chebula Retz. | Inhibition of cell proliferation by induction of apoptosis and cell-cycle arrest by regulation of the Bcl-2 family | Not identified | (Wang et al., 2015) |
| T. ferdinandiana Exell | Antiproliferative activity against carcinoma cell proliferation | Ethyl acetate extracts: (5) corilagin, (48) luteolin, (76) chebulic acid, (90) protocatechuic acid, (118) rutin, (91) punicalin, (53) chebulagic acid | (Shalom and Cock, 2018) |
| T. citrina (Gaertn.) Roxb. | Antiproliferative and antiestrogenic activity against MCF-7 cells; antiproliferative activity against T47D cell lines | (91) Terminaloside A, (77) terminaloside B, (80) terminaloside C, (92) terminaloside D, (93) terminaloside E, (81) terminaloside F, (78) terminaloside G, (94) terminaloside H, (82) terminaloside I, (95) terminaloside J, (96) terminaloside K, (97) 2-epiterminaloside D, and (79) 6-epiterminaloside K | (Muhit et al., 2016) |
| T. catappa L. | Inhibition of cellular migration and invasion in human HeLa and SiHa cervical cancer cell lines | Not identified | (Lee et al., 2018) |
| T. chebula Retz. | (86) Punicalagin, (85) geraniin, (76) chebulic acid, (9) chebulinic acid, (3) gallic acid | (Lee et al., 2016) | |
| T. chebula Retz. | Inhibition of the TNF-induced necroptotic cell death | (3) Gallic acid (hypothesized active compound), (85) geraniin, (76) chebulic acid, (86) punicalagin, (9) chebulinic acid, (53) chebulagic acid | |
| T. chebula Retz. | Chebulagic acid induces G1 arrest and induces apoptosis in retinoblastoma Y79 cells | (53) Chebulagic acid | (Kumar et al., 2014) |
| T. bellerica (Gaertn.) Roxb. | Induced apoptosis in human lung A459 and human breast MCF-7 cancer cell lines | (35) Quercetin, (3) gallic acid, (87) catechin, (89) tannic acid, (88) reserpine | (Ghate et al., 2014) |