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. 2020 Sep;12(9):4771–4780. doi: 10.21037/jtd-20-203

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2020 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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LncRNA KCNQ1OT1 is up-regulated in hypertrophic cardiomyocytes. (A) Immunofluorescence results for the effect of Ang-II on cell surface areas. (B) Changes in the expression of LINC00850, LINCMD1, MALAT1, and KCNQ1OT1 in cardiomyocytes under Ang-II. (C) Detection of the expression of KCNQ1OT1 in TAC and sham mice. (D) The mRNA expression of hypertrophy markers by RT-PCR. (E) Transfection efficiency of shKCNQ1OT1 by RT-PCR. *, P<0.05. TAC, transverse aortic constriction.