Table 1. Baseline characteristics of 692 patients with early-stage NSCLC and COPD.
| Surgery only (n=442) | Surgery with adjuvant treatment (n=157) | RT (n=48) | SC-only (n=45) | P values | |
|---|---|---|---|---|---|
| Age, yr | 68.0 (7.4) | 64.9 (6.7) | 72.8 (9.5) | 73.1 (6.8) | <0.001 |
| Male sex | 380 (86.0) | 141 (89.8) | 43 (89.6) | 43 (95.6) | 0.203 |
| Smoking status† | 0.007 | ||||
| Current smoker | 162 (36.7) | 77 (49.0) | 15 (31.3) | 19 (42.2) | |
| Former smoker | 203 (45.9) | 65 (41.4) | 28 (58.3) | 23 (51.1) | |
| Never smoker | 77 (17.4) | 15 (9.6) | 4 (8.3) | 2 (4.4) | |
| BMI (kg/m2)† | 23.7 (2.7) | 24.0 (2.9) | 22.3 (3.4) | 21.7 (3.1) | <0.001 |
| ECOG Performance Status‡ | <0.001 | ||||
| 0–1 | 439 (99.3) | 154 (98.1) | 33 (68.8) | 35 (77.8) | |
| 2–3 | 3 (0.7) | 3 (1.9) | 11 (22.9) | 2 (4.4) | |
| Unknown | 0 | 0 | 4 (8.3) | 8 (17.8) | |
| History of other cancer | 83 (18.8) | 11 (7.0) | 12 (25.0) | 6 (13.3) | 0.002 |
| Double primary cancer | 40 (9.1) | 8 (5.1) | 4 (8.3) | 4 (8.9) | 0.451 |
| Comorbidities | |||||
| Tuberculosis | 62 (14.0) | 25 (15.9) | 13 (27.1) | 9 (20.0) | 0.100 |
| Heart disease | 52 (11.8) | 17 (10.8) | 8 (16.7) | 9 (20.0) | 0.294 |
| Hypertension | 199 (45.0) | 63 (40.1) | 20 (41.7) | 20 (44.4) | 0.748 |
| Diabetes | 104 (23.5) | 24 (15.3) | 11 (22.9) | 6 (13.3) | 0.090 |
| Hemoglobin (g/dL)† | 12.9 (1.4) | 12.8 (1.5) | 12.8 (1.4) | 13.0 (1.6) | 0.701 |
| Tumor histology | <0.001 | ||||
| Adenocarcinoma | 250 (56.6) | 47 (29.9) | 13 (27.1) | 9 (20.0) | |
| Squamous cell carcinoma | 164 (37.1) | 95 (60.5) | 26 (54.2) | 26 (57.8) | |
| Other NSCLC | 28 (6.3) | 15 (9.6) | 2 (4.2) | 5 (11.1) | |
| Unknown | 0 | 0 | 7 (14.6) | 5 (11.1) | |
| Clinical stage | <0.001 | ||||
| I | 337 (76.2) | 59 (37.6) | 32 (66.7) | 27 (60.0) | |
| II | 105 (23.8) | 98 (62.4) | 16 (33.3) | 18 (40.0) |
Values are in mean (standard deviation) or number (%). †The number of patients with missing value was smoking status (n=2), BMI (n=4), and hemoglobin (n=3). ‡Performance status was based on Eastern Cooperative Oncology Group (ECOG) scale. BMI, body mass index; COPD, chronic obstructive pulmonary disease; ECOG PS, Eastern Cooperative Oncology Group Performance Status; NSCLC, non-small cell lung cancer; RT, radiotherapy; SC, supportive care.