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. 2020 Sep;12(9):5128–5139. doi: 10.21037/jtd.2019.08.37

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2020 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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A 79-year-old female diagnosed with metastatic Hurthle cell carcinoma presents radioactive iodine (RAI)-resistance. Initial FDG PET/CT shows increased metabolic activity in the recurrent metastasic right level II/III cervical chain lymph nodes (white arrows) in 2016. Six months after RAI therapy, follow-up FDG PET/CT in 2017 shows increased size and metabolic activity in the right level II/III cervical chain lymph nodes, indicating RAI-resistance. PET/CT, positron emission tomography/computed tomography; FDG, fluorodeoxyglucose; RAI, radioactive iodine.