Table 4.

Coefficients for the blip functions.

	Coefficient (95% CI)	P value
Blip function on day 1
Intercept	− 1.248(− 2.5,0.004)	0.118
Age (per 10-year increase)	− 0.067(− 0.163,0.029)	0.314
Unit type (CCU-CTICU as reference)
CSICU	0.413(0.37,0.455)	< 0.001
CTICU	0.078(− 0.072,0.228)	0.477
Cardiac ICU	0.215(0.184,0.245)	< 0.001
MICU	− 0.198(− 0.307,− 0.088)	0.001
Med-SurgICU	− 0.074(− 0.136,− 0.013)	0.048
Neuro ICU	1.485(1.438,1.532)	< 0.001
SICU	0.44(0.357,0.522)	< 0.001
HR1 (per 20-beat increase)	0.085(0.056,0.115)	< 0.001
MBP1 (per 20-mmHg increase)	0.707(0.227,1.188)	0.012
${\mathrm{MBP}}_1^2$	− 0.114(− 0.215,− 0.013)	0.041
MV1	0.357(0.066,0.648)	0.045
Blip function on day 3
Intercept	0.116(− 0.249,0.481)	0.657
Temperature3	− 0.004(− 0.006,− 0.002)	< 0.001
MBP3	− 0.163(− 0.281,− 0.045)	0.021
Urine output2	0.175(0.128,0.223)	< 0.001
Urine output1	0.019(− 0.02,0.058)	0.509
MV3	0.534(0.396,0.671)	< 0.001
Fluid strategy2	0.151(0.11,0.193)	< 0.001
Fluid strategy1	0.241(0.213,0.27)	< 0.001
Blip function on day 5
Intercept	− 0.557(− 0.807,− 0.308)	< 0.001
MV5	0.656(0.6,0.711)	< 0.001
HR5	0.002(0.001,0.002)	< 0.001
MBP5	− 0.002(− 0.008,0.004)	0.64
Fluid strategy3	0.115(− 0.136,0.366)	0.535
Fluid strategy4	0.432(0.198,0.666)	0.001
${\mathrm{Fluid}\mathrm{strategy}}_3\times {\mathrm{Fluid}\mathrm{strategy}}_4$	− 0.457(− 0.873,− 0.041)	0.039

Abbreviations: MBP: mean blood pressure; HR: heart rate; MV: mechanical ventilation; CCU-CTICU: coronary care unit- cardiothoracic ICU; CSICU: cardiac surgery ICU; CTICU: cardiothoracic ICU; SICU: surgical ICU; MICU: medical ICU.