Table 1. In vitro cytotoxicity of the target compounds (IC₅₀, nM) ^a .

Compound	COLO-357	BxPC-3	HaCaT	HEK293	L929
Colchicine (1)	16	16	3	16	2000
5a	16	16	16	16	>10 000
5b	400	80	80	400	>10 000
5c	16	16	3	3	2000
5d	80	80	80	80	>10 000
5e	16	3	3	16	2000
5f	80	16	16	16	2000
5g	16	16	16	16	2000
5h	80	16	16	80	2000
5i	3	3	0.6	3	80
5j	16	3	3	16	2000
12a	16	16	0.6	3	10 000
12b	400	400	400	400	2000
rac-13	80	16	16	16	— b

^aIC₅₀ concentration inducing 50% inhibition of cell growth.

^bNot determined.