Skip to main content
. Author manuscript; available in PMC: 2020 Oct 22.
Published in final edited form as: J Comput Aided Mol Des. 2013 Dec 1;27(12):1037–1049. doi: 10.1007/s10822-013-9695-x

Fig. 1.

Fig. 1

Comparison of DNA cleavage sites in the absence and presence of a Top1 poison. DNA is shown as green spheres. DNA structures obtained from crystal structures of covalent Top1-DNA complexes: PDB 1K4S (top panel, no ligand), and 1K4T (bottom panel, ligand bound) [27]