Table 1.
Distribution of cancer spectrum in Cep55 transgenic mice.
No. | Cancerous Lesions | Cep55wt/wt(n = 40) | Cep55wt/Tg(n = 40) | Cep55Tg/Tg(n = 50) | Cep55wt/wt vs Cep55Tg/Tg, Cep55wt/Tg vs Cep55Tg/Tg | ||||
---|---|---|---|---|---|---|---|---|---|
# | % | # | % | # | % | p valuesa | |||
1 | Lymphoma | 0 | 0 | 0 | 0 | 18 | 51.42 | 6.0 × 10−6 | 6.0 × 10−6 |
B-Cell Lymphoma | – | – | 11 | 61.11 | 0.0010 | 0.0010 | |||
T-Cell Lymphoma | – | – | 7 | 38.88 | 0.0159 | 0.0159 | |||
2 | Undifferentiated sarcoma | 0 | 0 | 0 | 0 | 9 | 25.71 | 0.0039 | 0.0039 |
Fibrosarcoma | – | – | 3 | 33.33 | 0.2509 | 0.2509 | |||
Hemangiosarcoma | – | – | 6 | 66.67 | 0.0317 | 0.0317 | |||
3 | Bronchogenic adenocarcinoma | 0 | 0 | 0 | 0 | 6 | 17.14 | 0.0317 | 0.0317 |
4 | Hepatocellular Carcinoma | 0 | 0 | 0 | 0 | 3 | 8.57 | 0.2509 | 0.2509 |
5 | Gastric Carcinoma | 0 | 0 | 0 | 0 | 5 | 14.28 | 0.0632 | 0.0632 |
6 | Intestinal Papillary Carcinoma | 0 | 0 | 0 | 0 | 3 | 8.57 | 0.2509 | 0.2509 |
7 | Myelogenous Leukemia | 0 | 0 | 0 | 0 | 7 | 20 | 0.0159 | 0.0159 |
8 | Hepatic Hyperplasia (foci of cellular alteration) | 1 | 2.22 | 4 | 8.69 | 12 | 34.28 | 0.0051 | 0.1019 |
9 | Splenic follicular Hyperplasia | 1 | 2.22 | 4 | 8.69 | 8 | 66.66 | 0.0398 | 0.5373 |
10 | Endometrial Hyperplasia | 0 | 0 | 0 | 0 | 4 | 33.33 | 0.1259 | 0.1259 |
11 | Lipoma | 0 | 0 | 0 | 0 | 1 | 2.9 | 1.0 | 1.0 |
12 | Alveolar-Bronchiolar Adenoma | 0 | 0 | 10 | 22.22 | 15 | 42.85 | 0.0001 | 0.6426 |
13 | Hepatoma | 0 | 0 | 2 | 4.34 | 2 | 5.7 | 0.5006 | 1.0 |
aP values: Fisher’s exact tests.