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. 2020 Oct 21;10:17884. doi: 10.1038/s41598-020-74927-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo expansion of target1- and target2-CAR T-cells after injection in immunodeficient mice (n = 3 to 5 per dosage). Each point shows transgene level or CAR T-cell number. (a) Comparison of target1-CAR T-cell level expressed in units of copies/μg gDNA and copies/μL blood. Blue and red points represent doses of 5 × 10⁶ and 10 × 10⁶ CAR+ cells/animal, respectively. (b) Comparison of target2-CAR T-cell level expressed in units of copies/μg gDNA and copies/μL blood. (c) Comparison of target2-CAR T-cell level expressed in units of copies/μg gDNA and CAR+ cell number quantified by flow cytometry. (d) Comparison of target2-CAR T-cell level expressed in units of copies/μL blood and CAR+ cell number quantified by flow cytometry.