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. 2020 Sep 1;24(20):11984–11997. doi: 10.1111/jcmm.15823

Figure 1.

Figure 1

CGRP/RAMP1 signalling is involved in the growth of transplanted endometrial tissue. A, Area of the implants on day 14 after cross‐transplantation of endometrial tissue from WT or RAMP1−/− mice into WT or RAMP1−/− mice. Data are expressed as the mean ± SD (n = 6 mice per group). *P < .05. Right‐hand panels show the typical appearance of implants in the WT → WT and RAMP1−/− → RAMP1−/− mice on day 14 after implantation. Scale bars, 2 mm. B, Double immunofluorescence staining of CD11b (red)/RAMP1 (green) and S100A4 (green)/RAMP1 (red) in implant tissue from WT → WT mice on day 14. Scale bars, 50 μm. C, Immunohistochemical staining of CGRP in lumbar DRG from WT → WT and RAMP1−/− → RAMP1−/− mice on days 0 and 14 after implantation. Scale bars, 100 μm. (Right panel) The level of mRNA encoding CGRP in the lumbar DRG from the WT → WT and RAMP1−/− → RAMP1−/− mice on day 14. Data are expressed as the mean ± SD (n = 4‐6 mice per group). D, Immunofluorescence staining of CGRP (green) in whole‐mount endometrial tissues from WT → WT and RAMP1−/− → RAMP1−/− mice on days 7 and 14. Scale bars, 200 μm