Figure 3.

Lymphangiogenesis in the endometrial tissue implants from WT → WT and RAMP1^−/− → RAMP1^−/− mice. A, Immunohistochemical staining of LYVE‐1 in endometrial implant sections from WT → WT and RAMP1^−/− → RAMP1^−/− mice on day 14. Scale bars, 200 μm. Arrows indicate LYVE‐1⁺ cells. B, LVD and LVA% in the endometrial tissue implants from WT → WT and RAMP1^−/− → RAMP1^−/− mice on days 0 and 14. Data are expressed as the mean ± SD (n = 4 mice per group). *P < .05. C, The level of mRNA encoding LYVE‐1, VEGFR3, Prox1, VEGF‐C and VEGF‐D in endometrial tissue implants from WT → WT and RAMP1^−/− → RAMP1^−/− mice on day 14. Data are expressed as the mean ± SD (n = 5 mice per group). *P < .05. D, Double immunofluorescence staining of LYVE‐1 (green)/RAMP1 (red), VEGF‐C (green)/RAMP1 (red) and VEGF‐D (green)/RAMP1 (red) in endometrial tissue implants from WT → WT mice on day 14. Scale bars, 50 μm