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. 2020 Aug 19;7(20):2001019. doi: 10.1002/advs.202001019

Figure 1.

Figure 1

Biphasic regulation of mesenchymal genes during hematopoietic differentiation of hPSCs. A) Schematic overview of hESC hematopoietic differentiation in the chemically defined system. B) PCA results show a clear stepwise fate switches from pluripotent cells to HPCs. C) The heatmap showing different expression of mesenchymal genes between the four populations of cells during hematopoietic differentiation of hESCs. D) The enrichment of “Mesenchyme development” gene set between the four populations of cells during hematopoietic differentiation of hESCs. E) The dynamic expression of mesenchymal genes between the different populations of cells derived from hESCs during hematopoietic differentiation. F) The dynamic expression of characteristic mesenchymal genes in the four populations of cells during hematopoietic differentiation of hESCs, as detected with real‐time PCR. G) The heatmap showing down‐regulation of epithelial genes during hematopoietic differentiation of hESCs. H) The expression of characteristic epithelial genes in the four populations of cells during hematopoietic differentiation of hESCs, as detected with real‐time PCR. NS, not significant and ***P < 0.001.