TABLE 1.

Combinatory effects of docetaxel and GSK2334470 in PCa cells

Cell lines	Doc:GSK Ratio	Combination Index (CI)			Mean ± SD	Interactions
		ED50	ED75	ED90
DU145	1:250	0.591	0.479	0.424	0.498 ± 0.085	Synergism
	1:500	0.534	0.513	0.532	0.526 ± 0.011	Synergism
	1:1000	0.606	0.591	0.607	0.601 ± 0.009	Synergism
	1:2000	0.785	0.759	0.757	0.767 ± 0.016	Moderate Synergism
	1:4000	1.060	0.945	0.857	0.954 ± 0.102	Nearly additive
PC3	1:250	0.232	0.302	0.441	0.325 ± 0.106	Synergism
	1:500	0.369	0.440	0.524	0.444 ± 0.078	Synergism
	1:1000	0.478	0.467	0.456	0.467 ± 0.011	Synergism
	1:2000	0.643	0.569	0.505	0.572 ± 0.069	Synergism
	1:4000	0.964	0.746	0.577	0.763 ± 0.194	Moderate Synergism
LNCaP	1:250	1.153	1.030	0.926	1.037 ± 0.114	Nearly additive
	1:500	1.011	0.940	0.883	0.945 ± 0.064	Nearly additive
	1:1000	1.003	0.928	0.877	0.936 ± 0.063	Nearly additive
	1:2000	0.877	0.755	0.677	0.769 ± 0.101	Nearly additive
	1:4000	0.827	0.802	0.841	0.824 ± 0.020	Nearly additive