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A schematic illustration showing that puerarin has inhibitory effects on osteolysis in vivo and RANKL‐induced osteoclast formation in vitro. Puerarin suppressed the inflammatory response and maintained balance in the bone environment. In addition, puerarin attenuated the upregulation of p65 phosphorylation and the activation of the downstream transcription factor NFATc1. Our results showed that puerarin inhibits osteoclastogenesis by inhibiting the NF‐κB signalling pathway
